Extracts of Cistanche Tubulosa for brain function - 100% certified organic
Chart 3.1: Effects of Cistanche tubulosa glycosides(CTG) on memory consolidation dysfunction of mice induced by Sodium Nitrite (X±SD)
Compare with model group , *P<0.05 (Difference) **P<0.01 (Significant
|Model|| ||18 ||88.2±106.2
| ||200||15 ||216.6±101.1**
| ||100||15 ||154.3±124.9
Reference: Effects of CTG on memory consolidation
dysfunction of mice, Cong Gao,(Traditional Chinese Drug Research and Clinical
- CTG 400?200mg/kg after oral application, mice can significant
prolong the incubation period caused by the memory damage done by sodium
- Scopolamine 600mg/kg after oral application has good memory protection
effect to memory damaged mice.
- While CTG 100mg/kg can prolong incubation
period, it has less efficacy.
Chart 4.1 Influences of Cistanche tubulosa glycosides(CTG) on learning and memory functions of
mice with insufficiency of kidney yang induced by hydrocortisone in diving
platform test (X±SD)
Compared with model group *P<0.05 **P<0.01
|Jinguishenqi Pills||1500||15(1)||1||191.7±109.8* ||0.93±0.96*
|(Medicine)|| || || || ||
T Test: Compared with model
group *P<0.05 **P<0.01?bracket in animal number indicates the death
number during test.
b: death number caused by hydrocortisone.
Summary: CTG 400, 200, 100mg and Jinguishenqi Pill (Medicine) 1500mg can significantly
improve the learning and memory functions of mice with insufficient kidney
yang induced by hydrocortisone. Improve the error times and incubation period
and reduce the death rates.
Reference: Influence of CTG on learning and memory
functions of mice with insufficiency of kidney yang induced by hydrocortisone,
Cong Gao, Chinese Journal of Basic Medicine in Traditional Chinese Medicine,
ACT AS AN ANTIOXIDANT TO PROTECT NEURONS FORM APOPTOSIS
Echinacoside inhibits the formation of reactive oxygen species
Laser confocal scanning show the fluorescence is 9.8, 89.6, 39.1 and 14.2
in normal control group, TNF? group and TNF? and echinacoside 10mg/L, 100mg/L
group respectively, indicating echinacoside decreases the formation of reactive
oxygen species in the cells exposed to TNF?.
(1)Echinacoside rescues the SHSY5Y
neuronal cells from TNF?-induced apoptosis, Min Deng, et al.European Journal
of Pharmacology, 2004,(505),11-18
(2) Echinacoside rescues the SHSY5Y neuronal
cells from TNF?-induced apoptosis, Min Deng, Chinese Pharmacological Bulletin,2005,21(2):169-74
Protection effect of Cistanche tubulosa glycosides(CTG) on apoptosis of neuron
cells introduced by MPP+
Normal neuron cells includes soma, axon and dentrite
Within the normal group, the neuronal cells has normal growth, and long axon.
In the group treated by MPP+ , neuron atrophy and axon disappoint
In the group treated by MPP and CTG, the growing condition of neuron is good and the axon
is growing long.
Reference: Major pharmacology study, CTG new drug materials
The scavenging abilities of Echinacoside
in different concentration on -OH2 O2-. And L. free radical in vitro
concluded that Echinacoside, the main constituent of phenylethanoid glycosides,
might scavenge many kind of free radicals, the scavenging abilities had the
concentration-dependent of direct ratio.
Reference: Anti-aging function study
on Echinacoside, . Acta Biochimica et Biophysica Sinica, 2004,20(3):183-187
ANTI-FREE RADICAL VIA INCREASE THE ACTIVITY
OF SOD Cistanche tubulosa glycosides
increase activity of SOD in 60Co radiated mice model
The activity of SOD in
radiated group decreased 46.8%, but in Cistanche tubulosa glycosides treated
group it increased 52.1% and 52.4% (Cistanche tubulosa glycosides 125mg/kg?Cistnche
glucosides 500mg/kg). This test demonstrates two groups has increase SOD activity
in significant rate.
Reference: Effects on CTG's anti-lipid peroxidation and
anti-radiation, Lin Lee, China Journal of Chinese Material Medicine,1997,22(6):364-367
Cistanche tubulosa glycosides inhibit thrombosis in artery-vein by-pass.
Compared with distilled water, CTG 200mg, 100mg had the effect of inhibiting
thrombus coagulation, preventing thrombosis. Inhibition bate were 16.4% and
Chart 7.1 The effect of CTG inhibit thrombosis in artery-vein by-pass
|Thrombus moist weight
|Distilled water|| ||10||44.9±3.83
Compared with distilled water *P<0.05, **P<0.01
200?100mg/kg had the effect of inhibiting thrombus coagulation, preventing
thrombosis?thrombus moist weight reduce significantly compared with distilled
Reference: Major pharmacology study, CTG new drug materials (Unpublished)
Cistanche tubulosa glycosides increase physical strength and
resistance to ischemia and toxic substances.
After few days of given CTG,
both CTG groups significantly prolong the lack of oxygen mice living time,
increase mice tolerance to oxygen insufficiency.
Both CTG groups presented
significantly longer weight bearing swimming time, it demonstrates an ideal
Cistanche tubulosa glycosides increase the tolerance
to ischemia, prolong living time in sodium nitrite
Reference: Effects of CTG
on oxygen insufficiency tolerance and fatigue tolerance, Zhiqiang Wang, Chinese
Traditional and Herbal Drugs) ,1996,27 (supplementaryissue):137-138
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