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FOUNTAINHEAD MEMOREGAIN

Extracts of Cistanche Tubulosa for brain function - 100% certified organic



Cistanche Tubulosa

General Info


US Patent

Research charts
(below)

Testimonials


The Brain has the ability to repair itself


Article Natural Vs Synthetic Vitamins


Memoregain - Scientific evidence.pdf

Echinacoside
(Memoregain's active ingredient)may work in Parkinson disease


The Protective Effects of Some Phenylethanoid Glycosides on the Mitomycin C Induced DNA Strand Breakage



Herbal Medicine and Treatments for Attention-Deficit / Hyperactivity Disorder (ADHD)




Chart 3.1: Effects of Cistanche tubulosa glycosides(CTG) on memory consolidation dysfunction of mice induced by Sodium Nitrite (XSD)

Group

Content
(mg/kg)
Animal No.
(S)
Incubation period
(S)
Control 14222.6102.9**
Model 18 88.2106.2
Scopolamine60017 200.7110.7**
CTG40014 176.6124.3*
 20015 216.6101.1**
 10015 154.3124.9
Compare with model group , *P<0.05 (Difference) **P<0.01 (Significant Difference)

Summary:
  1. CTG 400?200mg/kg after oral application, mice can significant prolong the incubation period caused by the memory damage done by sodium nitrite.
  2. Scopolamine 600mg/kg after oral application has good memory protection effect to memory damaged mice.
  3. While CTG 100mg/kg can prolong incubation period, it has less efficacy.
Reference: Effects of CTG on memory consolidation dysfunction of mice, Cong Gao,(Traditional Chinese Drug Research and Clinical Pharmacology),2005,16(3):162-164

LEARING ENHANCEMENT


Chart 4.1 Influences of Cistanche tubulosa glycosides(CTG) on learning and memory functions of mice with insufficiency of kidney yang induced by hydrocortisone in diving platform test (XSD)

Group

Content
(mg/kg)
Animal No.
(S)
Death No.b
(S)
Incubation Period
(Time/5min )
Error Times

Control 180217.183.4**0.670.49**
Model 118100.588.71.820.98
Jinguishenqi Pills150015(1)1191.7109.8* 0.930.96*
(Medicine)     
CTG400181193.2121.7*0.831.04*
 20019(1)0211.5108.7**0.790.85**
 100190202.0117.6*1.161.46
Compared with model group *P<0.05 **P<0.01
T Test: Compared with model group *P<0.05 **P<0.01?bracket in animal number indicates the death number during test.
b: death number caused by hydrocortisone.

Summary: CTG 400, 200, 100mg and Jinguishenqi Pill (Medicine) 1500mg can significantly improve the learning and memory functions of mice with insufficient kidney yang induced by hydrocortisone. Improve the error times and incubation period and reduce the death rates.

Reference: Influence of CTG on learning and memory functions of mice with insufficiency of kidney yang induced by hydrocortisone, Cong Gao, Chinese Journal of Basic Medicine in Traditional Chinese Medicine, ,2005,11(5):330-332

ACT AS AN ANTIOXIDANT TO PROTECT NEURONS FORM APOPTOSIS


Echinacoside inhibits the formation of reactive oxygen species

Laser confocal scanning show the fluorescence is 9.8, 89.6, 39.1 and 14.2 in normal control group, TNF? group and TNF? and echinacoside 10mg/L, 100mg/L group respectively, indicating echinacoside decreases the formation of reactive oxygen species in the cells exposed to TNF?.

Reference:
(1)Echinacoside rescues the SHSY5Y neuronal cells from TNF?-induced apoptosis, Min Deng, et al.European Journal of Pharmacology, 2004,(505),11-18
(2) Echinacoside rescues the SHSY5Y neuronal cells from TNF?-induced apoptosis, Min Deng, Chinese Pharmacological Bulletin,2005,21(2):169-74


Protection effect of Cistanche tubulosa glycosides(CTG) on apoptosis of neuron cells introduced by MPP+

Normal neuron cells includes soma, axon and dentrite

Within the normal group, the neuronal cells has normal growth, and long axon.

In the group treated by MPP+ , neuron atrophy and axon disappoint
In the group treated by MPP and CTG, the growing condition of neuron is good and the axon is growing long.

Reference: Major pharmacology study, CTG new drug materials (Unpublished)

ANTI-AGING CAPABILITY


The scavenging abilities of Echinacoside in different concentration on -OH2 O2-. And L. free radical in vitro

It was concluded that Echinacoside, the main constituent of phenylethanoid glycosides, might scavenge many kind of free radicals, the scavenging abilities had the concentration-dependent of direct ratio.

Reference: Anti-aging function study on Echinacoside, . Acta Biochimica et Biophysica Sinica, 2004,20(3):183-187

ANTI-FREE RADICAL VIA INCREASE THE ACTIVITY


OF SOD Cistanche tubulosa glycosides increase activity of SOD in 60Co radiated mice model

The activity of SOD in radiated group decreased 46.8%, but in Cistanche tubulosa glycosides treated group it increased 52.1% and 52.4% (Cistanche tubulosa glycosides 125mg/kg?Cistnche glucosides 500mg/kg). This test demonstrates two groups has increase SOD activity in significant rate.

Reference: Effects on CTG's anti-lipid peroxidation and anti-radiation, Lin Lee, China Journal of Chinese Material Medicine,1997,22(6):364-367
Cistanche tubulosa glycosides inhibit thrombosis in artery-vein by-pass.

Result:
Compared with distilled water, CTG 200mg, 100mg had the effect of inhibiting thrombus coagulation, preventing thrombosis. Inhibition bate were 16.4% and 19.6%.

Chart 7.1 The effect of CTG inhibit thrombosis in artery-vein by-pass on rat

Group

Content
(mg/kg)
Animal No.
(S)
Thrombus moist weight
(mg,xSD)
Distilled water 1044.93.83
Aspirin1001029.24.00**
CTG2001037.77.42*
 1001036.15.16*

Compared with distilled water *P<0.05, **P<0.01

Summary: CTG 200?100mg/kg had the effect of inhibiting thrombus coagulation, preventing thrombosis?thrombus moist weight reduce significantly compared with distilled water.

Reference: Major pharmacology study, CTG new drug materials (Unpublished)

ANTI-FATIGUE


Cistanche tubulosa glycosides increase physical strength and resistance to ischemia and toxic substances.

After few days of given CTG, both CTG groups significantly prolong the lack of oxygen mice living time, increase mice tolerance to oxygen insufficiency.
Both CTG groups presented significantly longer weight bearing swimming time, it demonstrates an ideal anti-fatigue efficacy.
Cistanche tubulosa glycosides increase the tolerance to ischemia, prolong living time in sodium nitrite

Reference: Effects of CTG on oxygen insufficiency tolerance and fatigue tolerance, Zhiqiang Wang, Chinese Traditional and Herbal Drugs) ,1996,27 (supplementaryissue):137-138


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